High sensitive- C reactive protein, periodontal parameters and periodontal microbiota after scaling-root planning plus Azithromycin as treatment of Chronic Periodontitis: A Randomized Clinical Trial

  • Jorge-Enrique Soto-Franco Universidad del Valle. Cali, Colombia.
  • Heberth-Fernando Aldana Universidad del Valle. Cali, Colombia.
  • Juan-Manuel Navia Odontólogo, Especialista en Periodoncia
  • Melissa Peláez Universidad del Valle. Cali, Colombia.
  • Jorge Quisoboni Universidad del Valle. Cali, Colombia.
  • María-Alexandra O'Meara Universidad del Valle. Cali, Colombia.
  • Adolfo Contreras Universidad del Valle. Cali, Colombia.

Abstract

clinical trial (RCT) determined the effect of
scaling and root planning plus azithromycin
(SRP+Azi) in serum C reactive protein
levels and other blood biomarkers, clinical
periodontal parameters and subgingival
microbial composition three months after
periodontal therapy.
Materials and Methods: Forty-nine
chronic periodontitis patients participated
in the study and were randomly assigned to a test group of 27 patients received one
session of scaling and root planning plus
oral azithromycin 500 mg daily for five
days (SRP+Azi) while, 27 patients in the
control group received the same single
session of scaling and root planning plus
placebo (SRP+Pb). A group of 25 subjects
presenting periodontal health-gingivitis
were included as a comparison group and
in them was determined clinical periodontal
parameters, blood parameters and microbiota
at baseline. Periodontitis groups received
a full mouth periodontal examination,
blood test and microbiological cultures at
baseline, and three months after therapy.
Primary outcome variable was the variation
in serum high sensitive C- reactive protein
(hs-CRP). Secondary outcome variables
were variation of triglycerides, High
density Cholesterol (HDL), low density
Cholesterol (LDL), fasting glucose, pocket
depth and microbial composition.
Results: Therapy with SRP+Azi do not
significantly reduce the plasmatic levels of
hs-CRP however, a positive trend was notice
(4,33 to 2,99 mg/l). This group obtained
also greater reduction of pocket depth (PD),
artery index and P. gingivalis and P intermedia
detection frequency when compared
to the SRP-placebo group (p<0.05). Other
blood biochemistry parameters did not
changed significantly in the test group. In
contrast, the control group increased the hs-
CRP levels after therapy and in some cases
a increase of pocket depth was detected.
Conclusions: Combined SRP+Azi therapy
in chronic periodontitis did not reduced hs-
CRP serum level significantly after three
months. However, this group reduced significantly
their probing pocket depth, reduced
P. gingivalis and P intermedia frequency
and increased clinical attachment gain.

Author Biographies

Jorge-Enrique Soto-Franco, Universidad del Valle. Cali, Colombia.

Odontólogo, Especialista en Periodoncia, Profesor titular de la Escuela de Odontología

Heberth-Fernando Aldana, Universidad del Valle. Cali, Colombia.

Odontólogo, Especialista en Periodoncia

Melissa Peláez, Universidad del Valle. Cali, Colombia.

Bacterióloga, Laboratorio de Virología

Jorge Quisoboni, Universidad del Valle. Cali, Colombia.

Odontólogo, Especialista en Periodoncia

María-Alexandra O'Meara, Universidad del Valle. Cali, Colombia.

Odontólogo, Especialista en Periodoncia

Adolfo Contreras, Universidad del Valle. Cali, Colombia.

Odontólogo, Magíster en Microbiología, Doctor en Biología Craneofacial, Profesor titular de la Escuela de Odontología

Published
2017-09-30
How to Cite
SOTO-FRANCO, Jorge-Enrique et al. High sensitive- C reactive protein, periodontal parameters and periodontal microbiota after scaling-root planning plus Azithromycin as treatment of Chronic Periodontitis: A Randomized Clinical Trial. Revista Estomatología, [S.l.], v. 24, n. 2, sep. 2017. ISSN 2248-7220. Available at: <http://revistas.univalle.edu.co/index.php/revista_estomatologia/article/view/5798>. Date accessed: 21 june 2018.
Section
Original Articles

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